ruinedchildhood:

But shit, it was 99 cents

ruinedchildhood:

But shit, it was 99 cents

shuckl:

rollinboy:

what the fuck
im trying to look up dangan ronpa and this????
who searched this on my computer???????????????????//

shuckl:

rollinboy:

what the fuck

im trying to look up dangan ronpa and this????

who searched this on my computer???????????????????//

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mightfallin:

whirrring:

thetiredgames:

Dachshund U.N.

For three weekends, 47 Dachshunds, more commonly known as Sausage Dogs, will attempt to solve the world’s Human Rights issues.”

this was so fucking important

"And they still accomplished more than the actual U.N."

spookyshire:

harryhickey:

MOZZARELLA STICKS ARE GROSS

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whycantibe1oftheoneswithacoolurl:

schrodingerscatisdead:

me at pokemon daycare

I had to reblog this again

whycantibe1oftheoneswithacoolurl:

schrodingerscatisdead:

me at pokemon daycare

I had to reblog this again

neurosciencestuff:

Study IDs new cause of brain bleeding immediately after stroke
By discovering a new mechanism that allows blood to enter the brain immediately after a stroke, researchers at UC Irvine and the Salk Institute have opened the door to new therapies that may limit or prevent stroke-induced brain damage.
A complex and devastating neurological condition, stroke is the fourth-leading cause of death and primary reason for disability in the U.S. The blood-brain barrier is severely damaged in a stroke and lets blood-borne material into the brain, causing the permanent deficits in movement and cognition seen in stroke patients.
Dritan Agalliu, assistant professor of developmental & cell biology at UC Irvine, and Axel Nimmerjahn of the Salk Institute for Biological Studies developed a novel transgenic mouse strain in which they use a fluorescent tag to see the tight, barrier-forming junctions between the cells that make up blood vessels in the central nervous system. This allows them to perceive dynamic changes in the barrier during and after strokes in living animals.
While observing that barrier function is rapidly impaired after a stroke (within six hours), they unexpectedly found that this early barrier failure is not due to the breakdown of tight junctions between blood vessel cells, as had previously been suspected. In fact, junction deterioration did not occur until two days after the event.
Instead, the scientists reported dramatic increases in carrier proteins called serum albumin flowing directly into brain tissue. These proteins travel through the cells composing blood vessels – endothelial cells – via a specialized transport system that normally operates only in non-brain vessels or immature vessels within the central nervous system. The researchers’ work indicates that this transport system underlies the initial failure of the barrier, permitting entry of blood material into the brain immediately after a stroke (within six hours).
“These findings suggest new therapeutic directions aimed at regulating flow through endothelial cells in the barrier after a stroke occurs,” Agalliu said, “and any such therapies have the potential to reduce or prevent stroke-induced damage in the brain.”
His team is currently using genetic techniques to block degradation of the tight junctions between endothelial cells in mice and examining the effect on stroke progression. Early post-stroke control of this specialized transport system identified by the Agalliu and Nimmerjahn labs may spur the discovery of imaging methods or biomarkers in humans to detect strokes as early as possible and thereby minimize damage.

neurosciencestuff:

Study IDs new cause of brain bleeding immediately after stroke

By discovering a new mechanism that allows blood to enter the brain immediately after a stroke, researchers at UC Irvine and the Salk Institute have opened the door to new therapies that may limit or prevent stroke-induced brain damage.

A complex and devastating neurological condition, stroke is the fourth-leading cause of death and primary reason for disability in the U.S. The blood-brain barrier is severely damaged in a stroke and lets blood-borne material into the brain, causing the permanent deficits in movement and cognition seen in stroke patients.

Dritan Agalliu, assistant professor of developmental & cell biology at UC Irvine, and Axel Nimmerjahn of the Salk Institute for Biological Studies developed a novel transgenic mouse strain in which they use a fluorescent tag to see the tight, barrier-forming junctions between the cells that make up blood vessels in the central nervous system. This allows them to perceive dynamic changes in the barrier during and after strokes in living animals.

While observing that barrier function is rapidly impaired after a stroke (within six hours), they unexpectedly found that this early barrier failure is not due to the breakdown of tight junctions between blood vessel cells, as had previously been suspected. In fact, junction deterioration did not occur until two days after the event.

Instead, the scientists reported dramatic increases in carrier proteins called serum albumin flowing directly into brain tissue. These proteins travel through the cells composing blood vessels – endothelial cells – via a specialized transport system that normally operates only in non-brain vessels or immature vessels within the central nervous system. The researchers’ work indicates that this transport system underlies the initial failure of the barrier, permitting entry of blood material into the brain immediately after a stroke (within six hours).

“These findings suggest new therapeutic directions aimed at regulating flow through endothelial cells in the barrier after a stroke occurs,” Agalliu said, “and any such therapies have the potential to reduce or prevent stroke-induced damage in the brain.”

His team is currently using genetic techniques to block degradation of the tight junctions between endothelial cells in mice and examining the effect on stroke progression. Early post-stroke control of this specialized transport system identified by the Agalliu and Nimmerjahn labs may spur the discovery of imaging methods or biomarkers in humans to detect strokes as early as possible and thereby minimize damage.

beyonceunofficial:

left is summer looks and right is “let me show u why i don’t “comb every morning” white ho”

doctor-korra-holmes-in-hogwarts:

shawarmababy:

chaaaaaaaaaaaaaaaaaarlie:

B I T C H - The Avengers

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Here I forced it to work

Sorry Coulson’s not in the last one.

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sliverdemon:

NASA sending Google’s Project Tango smartphone to space to improve flying robots

An experimental NASA robot could get a big upgrade thanks to Google. The two parties have been working together to integrate Google’s Project Tango smartphone prototype — which can detect and map….


SocioTech Tumblr @SliverDemon

Google has become so powerful that NASA scientists are asking them for help. All hail the Googleplex

sliverdemon:

NASA sending Google’s Project Tango smartphone to space to improve flying robots

An experimental NASA robot could get a big upgrade thanks to Google. The two parties have been working together to integrate Google’s Project Tango smartphone prototype — which can detect and map….

SocioTech Tumblr @SliverDemon

Google has become so powerful that NASA scientists are asking them for help.

All hail the Googleplex